Amino-dPEG®₄-t-boc-hydrazide

$150.00$750.00

Clear

PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses

Amino-dPEG®4-t-boc hydrazide, product number 10041, is a useful crosslinking reagent. The free amine reacts with carboxylic acids and their active esters to form an amide bond. The boc-protected hydrazide can be uncovered using formic or trifluoroacetic acid and then reacted with a carboxylic acid or active ester to form a hydrazone. Hydrazone bonds are acid labile, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as occur in lysosomes or the acidic extracellular microenvironments at sites of inflammation or tumor metastasis. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.

Potential applications for Amino-dPEG®4-t-boc hydrazide include dendrimer construction, side-chain modification of amino acids, and antibody-drug conjugates. This product could also act as a building block for releasable labels such as biotin or dye or releasable payloads such as a small molecule drug or peptide. Procedures for working with this product can be adapted from Bioconjugate Techniques, 3rd edition, by Greg Hermanson, which is also available from Quanta BioDesign.

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

To learn more about Quanta BioDesign’s dPEG® products and their potential uses, please click the links below.

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

 

Additional information

Weight.5 oz
Dimensions.75 × .75 × 2 in